Topbp1 rad51
Web1. feb 2016 · TOPBP1 is a key player in DNA replication and DNA damage signaling. In this issue, Moudry et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507042) uncover … Web15. jan 2024 · Conditional TopBP1 deletion resulted in reduced testis size, reduced number of epididymal sperm, increased apoptosis, and severely compromised fertility. TopBP1 …
Topbp1 rad51
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Web4. jan 2024 · c, d TopBP1 and BRCA1 recognize rRNA species in the XY body. Following RNase A treatment or excessive RNA blocking, TopBP1-BRCT5 ( c ) or BRCA1-BRCT ( d ) … Web21. júl 2024 · Here, we report that TOPBP1 interacts with the RNA-binding protein HTATSF1 in a cell-cycle- and phosphorylation-dependent manner. Mechanistically, CK2 …
Web25. jan 2016 · DNA strand breakage, one of the main types of DNA damage, enables Topoisomerase II-binding protein 1 (TopBP1) to induce ATR-Chk1 mediated checkpoint … Web25. jan 2016 · Because RAD51 phosphorylation at serine 14 and threonine 13 facilitates RAD51 recruitment to IR-induced damage sites (Yata et al., 2012), absence of RAD51 …
Web1. feb 2016 · Mechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 … National Center for Biotechnology Information Web10. jan 2024 · a Western blot analysis of TopBP1, RAD51, and GAPDH levels in HFK-, HFK-31-, and HPV31-positive CIN612 cells differentiated in high-calcium media for the …
WebThese findings confirm that TOPBP1 and MRE11, upstream components of the ATR pathway, are required for viability of PARP14-deficient cells. ... View in full-text Context 7 ... H3 phosphorylation...
WebThese panels are a focused compilation of genes based on their role in a biological process, disease, or pathway. Targets represent a diverse set of signaling molecules as well as upstream and downstream effectors. Panels were modeled after SAB PCR arrays and utilize PrimePCR expertly designed and experimentally validated assays. full cast of the watch bbcWeb21. júl 2024 · TOPBP1 loading RPA-RAD51 exchange Introduction Homologous recombination (HR) is a high-fidelity pathway in repairing of DNA double-strand breaks … gin and juice bottleWeb26. feb 2024 · TOP1 (transient breaking and rejoining of single-stranded DNA): Topoisomerase I; SRSF2 (RNA-binding protein): serine and arginine rich splicing factor 2; U2AF1 (splicing factor): U2 small nuclear RNA auxiliary factor 1; SETX (helicase): Senataxin; XRN2 (DNA incision): 5′-3′ exoribonuclease 2; DHX9 (helicase): DEAD box helicase 9; … gin and jonesWeb5. okt 2024 · Together, our study reveals an S-phase specific HTATSF1-nucleated PARylation and phosphorylation cascade that directs the HR-promoting activity of TOPBP1, and … full cast of thunderheartWeb11. nov 2024 · h, Quantification of CIP2A and HA-TOPBP1 mitotic IRIF in DLD1 cells expressing variants of sgRNA-resistant TOPBP1 (TOPBP1*) or EV encoding only the HA … full cast of the wedding plannerWeb8. jan 2024 · TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to … gin and juice bristol menuWeb14. apr 2024 · Following the binding of MDC1 (mediator of DNA damage checkpoint protein 1) to γH2AX, TOPBP1-ATR is further activated and confined to the sex body and promotes the γH2AX signal spread to the protruding loops of the chromatin at the mid-pachytene stage ( Ichijima et al., 2011; ElInati et al., 2024 ). gin and juice bristol book a table