Improving protein succinylation sites
WebMar 22, 2024 · Succinylation causes a protein charge flip from positive to negative and a relatively large increase in mass compared to other PTMs. Hundreds of protein succinylation sites are present in proteins of multiple tissues and species, and the significance is being actively investigated. WebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine …
Improving protein succinylation sites
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WebProtein succinylation is a type of post-translational modification (PTM) that occurs on lysine sites and plays a key role in protein conformation regulation and cellular function control. WebApr 5, 2016 · Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 is an efficient desuccinylase. Although many mammalian proteins have recently been found to be regulated by lysine succinylation and SIRT5, the physiological significance of succinylation and SIRT5 remains unknown.
WebFeb 12, 2024 · The original collection comprised 2,521 succinylation and 24,128 non-succinylation sites from 896 unique proteins. To avoid overestimations due to homology … WebImproving Protein Succinylation Sites Prediction Using Features Extracted from Protein Language Model Webserver http://kcdukkalab.org/LMSuccSite/ Authors Suresh Pokharel …
WebEnter the email address you signed up with and we'll email you a reset link. WebNov 23, 2024 · The increase of protein succinylation in zebrafish appeared to be larger in response to sucla2 deficiency than with loss of sirt5, confirming what was predicted by …
WebNov 11, 2024 · Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of …
WebJul 21, 2024 · Improving protein succinylation sites prediction using embeddings from protein language model. 2024, Scientific Reports. ... Accurate in silico identification of protein succinylation sites using an iterative semi-supervised learning technique. Journal of Theoretical Biology, Volume 374, 2015, pp. 60-65. dewalt 1/2 drive impact socket setsWebThe potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and … dewalt 1 2 impact brushlessWebApr 23, 2024 · Using an independent test set of experimentally identified succinylation sites, our method achieved efficiency scores of 79%, 68.7% and 0.48 for sensitivity, specificity … churchintheson live streamWebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, … dewalt 1/2 impact anvilWebOct 8, 2024 · Europe PMC is an archive of life sciences journal literature. church in the sky south carolinaWebOct 8, 2024 · A novel approach that combines features from supervised word embedding with embedding from a protein language model called ProtT5-XL-UniRef50 in a deep learning framework to predict protein succinylation sites is presented. Protein succinylation is an important post-translational modification (PTM) responsible for many vital … dewalt 1/2 gallon cordless vacuumWebJun 27, 2013 · After removing overlapping sites, we identified a total of 2,565 Lys succinylation sites from 779 proteins in mouse cells ( Figures 1 B and 1C). We found that some proteins were highly succinylated, including CPS1 with 47 sites and hydroxyacyl-coenzyme A dehydrogenase (HADHA) with 32 sites ( Figure 1 C and Tables S1 A–S1B). churchintheson online