Hyal2 protein
Web27 sep. 2024 · Cell surface HA binding proteins, such as CD44 and RHAMM, anchor the matrix to the cell (4, 5). The degradation of HA is catalyzed by hyaluronidase enzymes (6, 7). Hyal1 and Hyal2 are the major hyaluronidases that are expressed in most tissues and hydrolyze the linkage between N-acetylglucosamine and glucuronic acid to generate HA … Web30 nov. 2024 · HYAL2 is a cell-surface protein proposed to act as a hyaluronidase enzyme in concert with HYAL1, the other major mammalian hyaluronidase acting in somatic tissues, catalyzing the degradation of the high molecular weight glycosaminoglycan polymer hyaluronan., Hyaluronan, a core constituent of the extracellular matrix, plays key roles in …
Hyal2 protein
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Web1 sep. 2024 · OBJECTIVE: Hyaluronidases (HYAL1 and HYAL2) are key enzymes in the degradation of hyaluronan, and their expression has been altered in various cancer …
Web21 mrt. 2024 · HYAL2 (Hyaluronidase 2) is a Protein Coding gene. Diseases associated with HYAL2 include Cleft Lip And Palate-Craniofacial Dysmorphism-Congenital Heart Defect-Hearing Loss Syndrome and Mucopolysaccharidosis, Type Ix. Among its related … WebHYAL2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
WebProteins related to Hyal2 obtained by BLAST search of GenBank are shown. Proteins that exhibit high receptor activity when expressed in cells that are normally nonpermissive for JSRV and ENTV vector transduction are indicated by “+”, those that exhibit moderate receptor activity are indicted by “+/−”, and those that exhibit very low to no activity are … Web15 nov. 2002 · Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give …
WebRecombinant Human Hyaluronidase 2/HYAL2 His-tag Protein, CF Summary Learn more about Fluorescent Glycan Labeling and Detection Product Specifications Purity >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method. Activity
Hyaluronidase-2 is a multifunctional protein, previously thought to only possess acid-active hyaluronan-degrading enzymatic function. In humans it is encoded by the HYAL2 gene. This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosami… exterity boxWeb12 jan. 2024 · HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. exterity artiosignWebHyaluronidase-2 (HYAL2) (AA 21-448) protein (His tag) Crystallography grade HYAL2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, … exterior worlds landscaping \\u0026 designWebHyal2 induction was confirmed by using small interfering RNA (siRNA) expressing lentivirus. These in vitro findings correlated in vivo with smokers, where increased Hyal2 immunoreactivity in the epithelium was associated with augmented levels of HA and the appearance of low molecular mass HA species in bronchial secretions. exterity playerWeb12 jan. 2024 · HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. exterior wrought iron railing for stairsWeb1 nov. 2007 · The HYAL2 protein contains a N-terminal signal peptide (1-20) and a epidermal growth factor (EGF)-like domain (365-469). Description. The 473 amino-acid peptide encodes the HYAL2 protein with a predicted molecular weight of 53.9 KDa. exterior wood treatment productsWebPrestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution. Synonym (s): Anti-Hyaluronoglucosaminidase 2, Anti-LUCA2, … exterior wood window trim repair