WebJan 6, 2024 · Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors become treatment refractory. Pathologically, Ewing sarcoma consists of small round … Web张修云，袁静萍，阎红琳，吴昊 （武汉大学人民医院病理科，武汉430060） 促结缔组织增生性小圆细胞肿瘤（desmoplastic small round cell tumor，DSRCT）是一种高度恶性的小圆形细胞肿瘤，主要发生于青少年或年轻人的腹腔及盆腔，好发于男性。

Targeting the undruggable: exploiting neomorphic features of …

WebEWS, EWS-FLI1, bK984G1.4. EWS RNA-binding protein 1 (EWSR1) is a gene that encodes a protein that functions in gene expression, cell signaling, and RNA processing and transport. Fusions, rearrangements, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as ... WebSep 1, 2008 · Although p53 is the most frequently mutated gene in cancer, half of human tumors retain wild-type p53, whereby it is unknown whether normal p53 function is … gpp oite

FET(EWSR1)-TFCP2 Rhabdomyosarcoma: An Additional Example …

WebSep 14, 2016 · Impact of the EWSR1/ELF5 fusion transcript on the p53/p21 pathway promoting apoptosis. (a) Western blot analysis of U2OS cells trans-duced with EWSR1/ELF5 or the empty vector (MOCK). WebOnly scattered pleomorphic cells showed weak p53 expression. EWSR1 and TFE3 fluorescent in situ hybridization showed no rearrangement of the examined genes. The final diagnosis was metastasis of a malignant PEComa (grade III). In light of the histopathological results of the pulmonary lesion, the histological findings of the thigh tumor, which ... WebAug 1, 2014 · Request PDF Ewing sarcoma inhibition by disruption of EWSR1–FLI1 transcriptional activity and reactivation of p53 Translocations involving ETS … gp.ottavian