WebFeb 10, 2024 · We further investigated whether kindlin-2 loss impacts progression of a destabilization of the medial meniscus (DMM)-induced OA model. At 2 months of age, the K2fl/fl; AggrecanCreERT2 mice were... WebExperimental OA was induced in 12-week-old male mice (C57BL/6J) by destabilization of the medial meniscus (DMM) surgery as described by Glasson et al. . The medial meniscus tibial ligament was exposed without sectioning in sham surgery. Mice were sacrificed 8 weeks after DMM or sham surgery and subjected to histological analyses.
Mouse models of osteoarthritis: surgical model of
Webdifferences in a destabilized medial meniscus osteoarthritis model. Methods: Male and Female mice receive either a destabilized medial meniscus or sham procedure resulting in groups of n=5 (n=20 total). The mice were then allowed to explore a specialized gait arena to collect spatiotemporal data. Gait results were analyzed for gender differences. WebOsteoarthritis Mouse Model of Destabilization of the Medial Meniscus This chapter describes the surgical procedure for destabilization of medial meniscus in mice. Details on subsequent microCT and histological analysis are also provided, as well as details on osteoarthritis evaluation. copy of a file sc tax form
Osteoarthritis induced by destabilization of the medial meniscus …
WebMar 22, 2024 · 22 Mar 2024 All issues ONLINE COVER Mind the gp130. In this image of a mouse knee joint after medial meniscus destabilization, Safranin O staining reveals proteoglycan-rich cartilage (pink) at the joint surface, suggesting resistance to osteoarthritis. WebFeb 22, 2024 · To fill this knowledge gap, we examined the effect of intragastric and intraarticular metformin in an destabilization of the medial meniscus (DMM) model of OA in mice, known to cause destabilization of the joint which eventually leads to degeneration and pain of the joint, and investigated whether the anabolic and anti-catabolic effects of … WebAug 12, 2013 · 1. Make an incision of the skin on the medial side of patellar ligament using a #15 blade. 2. Fold back the skin and locate the patellar ligament (Figure 1). 3. Make an … famous people that invented things